The Sherman in game which I believe is the M4 variant had two historical weak points which were removed in the later variants - the driver and assistant access hatch with periscope bulges which protruded out of the upper front plate.
Similarly, there is also the MG port weak point that Gaijin has modelled into most of its tanks.
Those are easily penetrated at 500m with the PzGr39 from the 50L60 which the Puma is equipped with.
The lower front plate where the final drives are located is also vulnerable at <500m to the 50L50.